Pseudomembranous colitis is an inflammatory disease of the colon (see image below). It has changed in the last 100 years from a fatal disease caused by a postoperative event to, in the era of antibiotics, a commonly occurring complication of antibiotic use that may lead to serious morbidity but that usually is treated easily.
Colonic pseudomembranes of pseudomembranous colitis. Photographs courtesy of Eric M. Osgard, MD.
Colonic pseudomembranes of pseudomembranous colitis. Photographs courtesy of Eric M. Osgard, MD. - In the late 1800s, prior to the availability of antibiotics, Finney reported the first case of pseudomembranous colitis, calling it "diphtheritic colitis."[1]
- Hall and O'Toole first described Clostridium difficile in 1935.[2]
- C difficile was first implicated as a causative factor in pseudomembranous colitis in the 1970s
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